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Related post: Others: D. Sacks P. A. Scott C. Lane Senior Staff Fellow Staff Fellow Senior Investigator LPD, NIAID LPD, Uroxatral 10mg NIAID LIR, NIAID COOPERATING UNITS r/f any; UniveTsity of Arizona, Tucson, AZ (E. A. Petersen); Harvard Medical School, Boston, MA, (F. vonLichtenberg); Armauer Hanson Research Institute (AHRI), Addis Ababa, Ethiopia, (G. Bjune); Institute of Dermatology, Santa Domingo-, Dominican Republic (H. Bogaert). LAB/BRANCH Laboratory of Parasitic Diseases SECTION Cell Biology and Immunology INSTITUTE AND LOCATION NIAID, NIH, Bethesda, Maryland 20205 TOTAL MAN-YEARS: 1.2 PROFESSIONAL: 0.7 OTHER: 0.5 CHECK APPROPRIATE BOX(ES) H (a) Human subjects S (a1) Minors D (a2) Interviews SI (b) Human tissues D (c) Neither SUMMARY Uroxatral Price OF WORK (Use standard unreduced type. Do not exceed the space provided.) This project continues to focus upon leishmaniasis. The studies involve characterization of parasites recovered from patients, use of experimental models of leishmanial infection in genetic in-bred strains of mice, and examination of the immune response in Uroxatral 10 Mg humans with various clinical forms of leishmanial infections. In addition to the group of L. aethiopica isolates from recently studied cutaneous disease cases from Ethiopia, we have accumulated 6 further isolates from widely scattered regions of the world (Peru, Dominican Republic, Afghanistan and Morocco, which are in process of characterization. Some exceptions to the original general pattern of heat sensitivity of species has turned up; one member of the L. mexicana complex and the L. aethiopica isolates were found to be sensitive to 35°C. Our sequential studies of the histopathology of leishmanial lesions in the ears of BALB/c mice are continuing, and we have confirmed Buy Uroxatral late metastatic spread of L. m. amazonensis in the resistant C3H mouse with a cloned isolate of the parasite. Work on the cell-mediated immune response in humans with leishmanial infection has comentrated mainly on assay of interleukin 2 (IL-2) and gamma interferon (gamma- INF) produced in lymphocyte cultures. We have also started to generate these lymphokines, along with lymphocyte blastogenesis to mitogens and antigens, using lymphocyte subsets --namely, unfractionated, total T cells and T 4 cells. A trial of gamma- INF therapy in two patients with diffuse cutaneous leishmaniasis is underway, but final results are not yet available. 10-15 PHS 6040 (Rev. 1/84) sPo gi4-si8 DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT PROJECT NUMBER ZOl AI 00103-18 LPD PERKDD COVERED October 1, 1984 to September 30, 1985 TITLE OF PROJECT (80 characters or less. Title rr)ust fit on one line between the borders.) Immunological Studies on Toxoplasmosis and Other Parasitic Diseases PRINCIPAL INVESTIGATOR (List other professional personnel below the Principal Investigator.) (Name, title, laboratory, Uroxatral Coupon and institute affiliation) PI: M. N. Lunde Research Zoologist LPD, NIAID Others: A. W. Cheever L. Jacobs T. E. Nash H. Uroxatral Cost Masur M. G. Pappas Assistant Chief Scientist Emiritus Senior Investigator Deputy Chief Dept. Immunology LPD, NIAID NIAID LPD, NIAID CCM, CC WRAIR COOPERATING UNITS (if any) Critical Care Medicine, Clinical Center, NIH Department of Immunology, WRAIR LAB/BRANCH Laboratory of Parasitic Diseases SECTION Host-Parasite Relations Section INSTITUTE AND LOCATION NIAID, NIH, Bethesda, Maryland 20205 TOTAL MAN-YEARS; 1.5
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